Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.38 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91294 | 0.85 | PARP1 (0.39) | ELANEPDK1PDK2PDK3PDK4 | |
| SCHEMBL65230 | 0.84 | MAPT (0.33) | — | |
| SCHEMBL21235743 | 0.79 | ELANE (0.46) | ELANEPARP1 | |
| SCHEMBL15185033 | 0.79 | NPC1 (0.43) | ELANEPDK1PDK2PDK3PDK4 | |
| SCHEMBL66855 | 0.78 | ELANE (0.38) | ELANE | |
| SCHEMBL13032699 | 0.78 | ELANE (0.48) | ELANEPARP1 | |
| SCHEMBL29560191 | 0.77 | SMN1; SMN2 (0.45) | ELANEPDK1PDK2PDK3PDK4 | |
| SCHEMBL34466974 | 0.77 | PREP (0.42) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL30781571 | 0.77 | PREP (0.42) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL78361 | 0.77 | PARP1 (0.43) | PDK1PDK2PDK3PDK4PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |