Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL65686 | 0.81 | PDK1 (0.38) | KDM1ARCOR1 | |
| SCHEMBL15185033 | 0.79 | NPC1 (0.43) | ELANE | |
| SCHEMBL78184 | 0.78 | ELANE (0.39) | ELANE | |
| SCHEMBL64035 | 0.78 | SLC6A2 (0.37) | — | |
| SCHEMBL29560191 | 0.76 | SMN1; SMN2 (0.45) | ELANE | |
| SCHEMBL65814 | 0.76 | PPARG (0.39) | — | |
| SCHEMBL65299 | 0.75 | LTA4H (0.35) | — | |
| SCHEMBL16080271 | 0.74 | ACE2 (0.40) | — | |
| SCHEMBL65685 | 0.73 | CHRM5 (0.40) | ELANE | |
| SCHEMBL29510871 | 0.73 | PDK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129538-B1 | Renin inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-03-06 | — | — | US | disclosed |