SCHEMBL7818677

SCHEMBL7818677

Cc1cc(=O)[nH]c2c1C(=O)c1cc(C)c(=O)[nH]c1C2=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.33
CYP2C19 P33261 1/20 0.33
TNKS2 Q9H2K2 1/20 0.33
ATAD2 Q6PL18 1/20 0.32
BRD4 O60885 1/20 0.32
GRIN2D O15399 1/20 0.31
GRIN3B O60391 1/20 0.31
GRIN1 Q05586 1/20 0.31
GRIN2A Q12879 1/20 0.31
GRIN2B Q13224 1/20 0.31
GRIN2C Q14957 1/20 0.31
GRIN3A Q8TCU5 1/20 0.31
KDM4E B2RXH2 2/20 0.30
UPP1 Q16831 1/20 0.30
JAK1 P23458 1/20 0.30
TP53 P04637 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
RECQL P46063 1/20 0.30
TDP1 Q9NUW8 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29272751 0.82 BRD4 (0.39) CYP1A2ATAD2BRD4GRIN2DGRIN3B
SCHEMBL14873867 0.82 CYP1A2 (0.41) CYP1A2CYP2C19TNKS2GRIN2DGRIN3B
Marcanin A SCHEMBL29923975 0.76 RAB9A (0.47) CYP1A2CYP2C19TNKS2KDM4ETP53
SCHEMBL20415202 0.73 TNKS2 (0.37) CYP1A2CYP2C19TNKS2KDM4EUPP1
SCHEMBL30201452 0.72 TNKS2 (0.46) CYP1A2CYP2C19TNKS2KDM4ETP53
SCHEMBL16380987 0.71 GRIN2D (0.37) CYP1A2CYP2C19TNKS2GRIN2DGRIN3B
SCHEMBL8916400 0.70 RAB9A (0.48) CYP1A2CYP2C19BRD4KDM4ETP53
SCHEMBL7822034 0.69 KMT2A (0.45) KDM4EJAK1ALDH1A1HPGD
SCHEMBL16380986 0.68 AR (0.36) CYP1A2CYP2C19TNKS2GRIN2DGRIN3B
SCHEMBL7815625 0.67 TNKS2 (0.32) TNKS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0695752-B1 ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIV MADRID COMPLUTENSE (ES) 2001-06-06 EP disclosed
EP-0695752-B1 ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIV MADRID COMPLUTENSE (ES) 2001-06-06 EP disclosed
US-5716963-A DIAZAQUINOMYCIN DERIVATIVE UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1998-02-10 US disclosed
US-5716963-A DIAZAQUINOMYCIN DERIVATIVE UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1998-02-10 US disclosed
EP-0695752-A1 NEW ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1996-02-07 EP disclosed
EP-0695752-A1 NEW ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1996-02-07 EP disclosed
WO-1995023145-A1 NEW ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1995-08-31 WO disclosed