Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28015830 | 0.83 | CA1 (0.42) | CA1CA2CA12CA7CA14 | |
| SCHEMBL8343913 | 0.81 | CA1 (0.43) | CA1CA2CA12CA7CA14 | |
| SCHEMBL28789776 | 0.80 | CA2 (0.39) | CA1CA2CA12CA7CA14 | |
| SCHEMBL780325 | 0.79 | ALDH1A1 (0.42) | CA1CA2CA12CA7CA14 | |
| SCHEMBL15215211 | 0.77 | CA2 (0.40) | CA1CA2CA12CA7CA14 | |
| SCHEMBL779221 | 0.76 | CA1 (0.39) | CA1CA2CA12CA7CA14 | |
| SCHEMBL14779741 | 0.76 | CA1 (0.56) | CA1CA2CA12CA7CA14 | |
| SCHEMBL27224580 | 0.75 | RECQL (0.43) | CA1CA2CA12CA7CA14 | |
| SCHEMBL126898 | 0.75 | CA1 (0.65) | CA1CA2CA12CA7CA14 | |
| SCHEMBL9343626 | 0.74 | ALDH1A1 (0.42) | CA1CA2CA12CA7CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2297081-B1 | 1-(2-ETHYL-BUTYL)-CYCLOHEXANECARBOXYLIC ACID ESTER AS AN INTERMEDIATE IN THE PREPARATION OF PHARMACEUTICALLY ACTIVE AMIDES | HOFFMANN LA ROCHE (CH) | 2017-03-08 | — | — | EP | disclosed |
| EP-2274278-B1 | NEW PROCESS FOR THE PREPARATIION OF CYCLOHEXANECARBOXYLIC ACID DERICATIVES | HOFFMANN LA ROCHE (CH) | 2016-08-17 | — | — | EP | disclosed |
| US-20160200672-A1 | NEW PROCESS | HOFFMANN-LA ROCHE INC. | 2016-07-14 | — | — | US | disclosed |
| CN-101981001-B | Prepare the new method of naphthenic acid derivant | 弗·哈夫曼-拉罗切有限公司 | 2016-06-08 | — | — | CN | disclosed |
| US-20150361034-A1 | NEW PROCESS | HOFFMANN-LA ROCHE INC. | 2015-12-17 | — | — | US | disclosed |
| EP-2616433-B1 | PROCESS FOR PREPARING A CYCLOHEXANECARBONITRILE DERIVATIVE | HOFFMANN LA ROCHE (CH) | 2015-12-09 | — | — | EP | disclosed |
| US-20140336403-A1 | PROCESS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-11-13 | — | — | US | disclosed |
| CN-102066311-B | 1-(2-ethyl-butyl) -cyclohexanecarboxylic acid ester as an intermediate in the preparation of pharmaceutically active amides | HOFFMANN LA ROCHE | 2014-07-02 | — | — | CN | disclosed |
| CN-101952236-B | New process for the preparation of cyclohexanecarboxylic acid derivatives via the corresponding cyclohexanecarboxamide derivative | HOFFMANN LA ROCHE | 2014-07-02 | — | — | CN | disclosed |
| EP-2274264-B1 | NEW PROCESS FOR THE PREPARATION OF CYCLOHEXANECARBOXYLIC ACID DERIVATIVES VIA THE CORRESPONDING CYCLOHEXANECARBOXAMIDE DERIVATIVE | HOFFMANN LA ROCHE (CH) | 2014-02-12 | — | — | EP | disclosed |
| CN-101573319-A | Process for preparing 1- (2-ethyl-butyl) -cyclohexanecarboxylic acid | HOFFMANN LA ROCHE (CH) | 2009-11-04 | — | — | CN | disclosed |
| US-20090253927-A1 | PROCESS FOR CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | HOFFMANN-LA ROCHE, INC. | 2009-10-08 | — | — | US | disclosed |
| WO-2009121788-A1 | NEW PROCESS FOR THE PREPARATIION OF CYCLOHEXANECARBOXYLIC ACID DERICATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-08 | — | — | WO | disclosed |
| WO-2009121789-A1 | NEW PROCESS FOR THE PREPARATION OF CYCLOHEXANECARBOXYLIC ACID DERIVATIVES VIA THE CORRESPONDING CYCLOHEXANECARBOXAMIDE DERIVATIVE | F. HOFFMANN-LA ROCHE AG (CH) | 2009-10-08 | — | — | WO | disclosed |
| US-20090253928-A1 | PREPARATION FOR A CYCLOHEXANECARBOXYLIC ACID DERIVATIVE AND INTERMEDIATES | HOFFMANN-LA ROCHE, INC. | 2009-10-08 | — | — | US | disclosed |
| US-20090240080-A1 | PROCESS FOR THE PREPARATION OF CETP(1) | HOFFMANN URSULA | 2009-09-24 | — | — | US | disclosed |
| EP-2094636-A1 | PROCESS FOR PREPARING 1-(2-ETHYL-BUTYL)-CYCLOHEXANECARBOXYLIC ACID | F. Hoffmann-Roche AG (CH) | 2009-09-02 | — | — | EP | disclosed |
| US-20080154059-A1 | PROCESS FOR THE PREPARATION OF CETP(1) | HOFFMANN-LA ROCHE INC. | 2008-06-26 | — | — | US | disclosed |
| WO-2008074677-A1 | PROCESS FOR PREPARING 1- (2-ETHYL-BUTYL) -CYCLOHEXANECARBOXYLIC ACID | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-26 | — | — | WO | disclosed |
| EP-1935867-A1 | Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid | F. HOFFMANN-LA ROCHE AG (CH) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160200672-A1 | NEW PROCESS | CYP4A11, UGT1A1, CYP11B1 | CA1 3207/4885CA2 4156/4885CA12 2005/4885 |
| US-20080154059-A1 | PROCESS FOR THE PREPARATION OF CETP(1) | CETP, CES1, CPA1 | CA1 2573/4885CA2 1923/4885CA12 2510/4885 |
| US-20150361034-A1 | NEW PROCESS | CYP4A11, UGT1A1, CYP11B1 | CA1 3207/4885CA2 4156/4885CA12 2005/4885 |
| US-20090240080-A1 | PROCESS FOR THE PREPARATION OF CETP(1) | CETP, CES1, CPA1 | CA1 2573/4885CA2 1923/4885CA12 2510/4885 |
| US-20090253927-A1 | PROCESS FOR CYCLOHEXANECARBOXYLIC ACID DERIVATIVES | CYP2C9, CYP51A1, CYP2B6 | CA1 404/4885CA2 590/4885CA12 755/4885 |
| US-20090253928-A1 | PREPARATION FOR A CYCLOHEXANECARBOXYLIC ACID DERIVATIVE AND INTERMEDIATES | CYP2A13, CYP1A1, CYP2C19 | CA1 431/4885CA2 934/4885CA12 696/4885 |
| US-20140336403-A1 | PROCESS | UGT1A1, CYP3A7, CYP2F1 | CA1 2253/4885CA2 3834/4885CA12 1386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.