Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 7/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312265 | 0.94 | PDK2 (0.45) | MAPK1SMN1; SMN2PDK2KMT2ATHRB | |
| SCHEMBL11401106 | 0.86 | MAPK1 (0.42) | MAPK1SMN1; SMN2PDK2KMT2ATHRB | |
| SCHEMBL9631976 | 0.83 | MAPK1 (0.73) | MAPK1SMN1; SMN2PDK2KMT2ASLC6A2 | |
| SCHEMBL8200284 | 0.76 | MAPK1 (0.47) | MAPK1SMN1; SMN2KMT2AKDM4EL3MBTL1 | |
| SCHEMBL2151191 | 0.76 | MAPK1 (0.77) | MAPK1SMN1; SMN2L3MBTL1CHRM2CHRM1 | |
| SCHEMBL8199172 | 0.74 | MAPK1 (0.46) | MAPK1SMN1; SMN2KMT2ATDP1SLC6A2 | |
| SCHEMBL19154335 | 0.74 | CHRM3 (0.49) | MAPK1SMN1; SMN2KMT2AL3MBTL1CHRM2 | |
| SCHEMBL1394180 | 0.73 | KMT2A (0.40) | PDK2KMT2A | |
| SCHEMBL20833151 | 0.72 | SLC6A4 (0.40) | MAPK1PDK2KMT2ATHRBTDP1 | |
| SCHEMBL1395101 | 0.71 | PDK2 (0.41) | PDK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869954-B1 | HETEROCYCLIC COMPOUNDS FOR USE IN THE TREATMENT OF NEUROGENIC INFLAMMATION | NOVO NORDISK AS (DK) | 2001-09-19 | — | — | EP | disclosed |
| EP-0869954-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1998-10-14 | — | — | EP | disclosed |
| WO-1996031499-A1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK A/S (DK) | 1996-10-10 | — | — | WO | disclosed |