Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 7/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819239 | 0.94 | MAPK1 (0.49) | PDK2MAPK1SMN1; SMN2KMT2ATHRB | |
| SCHEMBL11401106 | 0.81 | MAPK1 (0.42) | PDK2MAPK1SMN1; SMN2KMT2ATHRB | |
| SCHEMBL1395101 | 0.79 | PDK2 (0.41) | PDK2KMT2A | |
| SCHEMBL9631976 | 0.78 | MAPK1 (0.73) | PDK2MAPK1SMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL1394180 | 0.77 | KMT2A (0.40) | PDK2KMT2A | |
| SCHEMBL4451439 | 0.73 | KMT2A (0.38) | PDK2KMT2A | |
| SCHEMBL9904949 | 0.72 | APAF1 (0.41) | PDK2MAPK1SMN1; SMN2ALDH1A1ATM | |
| SCHEMBL18552511 | 0.72 | IDO1 (0.61) | PDK2MAPK1KMT2AALDH1A1OPRM1 | |
| SCHEMBL18552508 | 0.72 | IDO1 (0.61) | PDK2MAPK1KMT2AALDH1A1OPRM1 | |
| SCHEMBL20833151 | 0.72 | SLC6A4 (0.40) | PDK2MAPK1KMT2ATHRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162824-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ALLELIX NEUROSCIENCE INC. | 2000-12-19 | — | — | US | disclosed |
| WO-1999041227-A1 | TRICYCLIC COMPOUNDS AS GLYCINE TRANSPORT INHIBITORS | ALLELIX NEUROSCIENCE, INC. (US) | 1999-08-19 | — | — | WO | disclosed |