SCHEMBL7819409

SCHEMBL7819409

O=C1CCc2c(CP(=O)(O)O)cccc21

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.49
GAA P10253 1/20 0.49
ACP3 P15309 2/20 0.45
GRIN2D O15399 1/20 0.43
GRIN3B O60391 1/20 0.43
GRIN1 Q05586 1/20 0.43
GRIN2A Q12879 1/20 0.43
GRIN2B Q13224 1/20 0.43
GRIN2C Q14957 1/20 0.43
GRIN3A Q8TCU5 1/20 0.43
PGK1 P00558 3/20 0.38
PGK2 P07205 3/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
ABCB1 P08183 2/20 0.36
MAPK1 P28482 1/20 0.36
KDM4E B2RXH2 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8020021 0.77 ALDH1A1 (0.53) ALDH1A1GAAABCB1KDM4EHPGD
SCHEMBL1151568 0.77 ALDH1A1 (0.59) ALDH1A1GAAABCB1KDM4EHPGD
SCHEMBL7812602 0.75 ALDH1A1 (0.50) ALDH1A1GAAABCB1KDM4EHPGD
SCHEMBL8004072 0.75 ALDH1A1 (0.54) ALDH1A1GAAGRIN2DGRIN3BGRIN1
SCHEMBL7846530 0.73 ALDH1A1 (0.52) ALDH1A1GAASMN1; SMN2ABCB1KDM4E
SCHEMBL9455878 0.72 ALDH1A1 (0.62) ALDH1A1GAAABCB1MAPK1KDM4E
SCHEMBL1861726 0.72 ALDH1A1 (0.48) ALDH1A1GAAABCB1KDM4EHPGD
SCHEMBL28069870 0.72 ALDH1A1 (0.48) ALDH1A1GAAABCB1KDM4EHPGD
SCHEMBL27531474 0.72 ALDH1A1 (0.55) ALDH1A1GAAABCB1MAPK1KDM4E
SCHEMBL9456183 0.72 ALDH1A1 (0.51) ALDH1A1GAAABCB1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880522-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES AMPA AND NMDA RECEPTORS ANTAGONISTS, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME AVENTIS PHARMA SA (FR) 2001-09-19 EP disclosed
EP-0880522-A1 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME Aventis Pharma S.A. (FR) 1998-12-02 EP disclosed
WO-1997025328-A1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF, INTERMEDIATES THEREOF AND DRUGS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1997-07-17 WO disclosed