Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7846530 | 0.81 | ALDH1A1 (0.52) | ALDH1A1GAAKDM4EMAPTABCB1 | |
| SCHEMBL9456120 | 0.80 | ALDH1A1 (0.48) | ALDH1A1GAAAKR1B1KDM4EMAPT | |
| SCHEMBL9456183 | 0.80 | ALDH1A1 (0.51) | ALDH1A1GAAAKR1B1KDM4EABCB1 | |
| SCHEMBL1151568 | 0.78 | ALDH1A1 (0.59) | ALDH1A1GAAKDM4EABCB1 | |
| SCHEMBL7812602 | 0.77 | ALDH1A1 (0.50) | ALDH1A1GAAKDM4EMAPTABCB1 | |
| SCHEMBL11631564 | 0.76 | ALDH1A1 (0.47) | ALDH1A1GAACTDSP1CYP1A2MRGPRX4 | |
| SCHEMBL6322288 | 0.75 | AKR1B1 (0.48) | GAAAKR1B1TDP1DUSP3PTPN5 | |
| SCHEMBL9517001 | 0.75 | AKR1B1 (0.43) | ALDH1A1AKR1B1TDP1DUSP3PTPN5 | |
| SCHEMBL7819409 | 0.75 | ALDH1A1 (0.49) | ALDH1A1GAAGRIN2DGRIN3BGRIN1 | |
| SCHEMBL569778 | 0.74 | ALDH1A1 (0.47) | ALDH1A1GAAMAPTMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100264-A | 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them | RHONE-POULENC RORER, S.A. (FR) | 2000-08-08 | — | — | US | disclosed |
| US-6057454-A | USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS | RHONE-POULENC RORER S.A. (FR) | 2000-05-02 | — | — | US | disclosed |
| US-5990108-A | USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR | RHONE POULENC RORER S.A. (FR) | 1999-11-23 | — | — | US | disclosed |
| US-5902803-A | 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives | RHONE-POULENC RORER S.A. (FR) | 1999-05-11 | — | — | US | disclosed |
| CN-1207102-A | 5h,10h-imidazo[1,2-alpha] indeno [1,2-3] pyrazine-4-one derivatives preparation thereof, intermediates thereof and drugs containing same | RHONE POULENC RORER SA (FR) | 1999-02-03 | — | — | CN | disclosed |