SCHEMBL7846530

SCHEMBL7846530

CNC(=O)Cc1cccc2c1CCC2=O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.52
GAA P10253 3/20 0.52
KDM4E B2RXH2 2/20 0.36
MALT1 Q9UDY8 1/20 0.35
MTNR1A P48039 3/20 0.35
ABCB1 P08183 2/20 0.34
CA12 O43570 1/20 0.34
CA2 P00918 1/20 0.34
POLB P06746 1/20 0.34
CA9 Q16790 1/20 0.34
APAF1 O14727 1/20 0.34
TDP2 O95551 1/20 0.34
NSD2 O96028 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4C Q9H3R0 1/20 0.34
SAE1 Q9UBE0 1/20 0.34
UBA2 Q9UBT2 1/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8004072 0.81 ALDH1A1 (0.54) ALDH1A1GAAKDM4EABCB1MAPT
SCHEMBL9456183 0.78 ALDH1A1 (0.51) ALDH1A1GAAKDM4EABCB1CA2
SCHEMBL1151568 0.77 ALDH1A1 (0.59) ALDH1A1GAAKDM4EABCB1KMT2A
SCHEMBL9456120 0.75 ALDH1A1 (0.48) ALDH1A1GAAKDM4EABCB1MAPT
SCHEMBL7847650 0.74 ACHE (0.34) ALDH1A1GAAKDM4EMALT1MTNR1A
SCHEMBL7819409 0.73 ALDH1A1 (0.49) ALDH1A1GAAKDM4EABCB1SMN1; SMN2
SCHEMBL9455878 0.72 ALDH1A1 (0.62) ALDH1A1GAAKDM4EABCB1KMT2A
SCHEMBL7812602 0.72 ALDH1A1 (0.50) ALDH1A1GAAKDM4EABCB1MAPT
SCHEMBL11631564 0.71 ALDH1A1 (0.47) ALDH1A1GAAKMT2A
SCHEMBL27407864 0.71 PTPRC (0.40) ALDH1A1GAAKDM4EMALT1MTNR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0820455-B1 5H, 10H-IMIDAZO [1,2-a]INDENO [1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES AVENTIS PHARMA SA (FR) 2001-10-31 EP disclosed
US-6057454-A USEFUL FOR TREATING OR PREVENTING ALL ISCHAEMIAS (SUCH AS FOCAL OR GLOBAL ISCHAEMIA) RESULTING FROM CEREBROVASCULAR DISORDERS RHONE-POULENC RORER S.A. (FR) 2000-05-02 US disclosed
US-5902803-A 5H,10H-imidazo 1,2-a!indeno 1,2-e!pyrazin-4-one derivatives, preparation thereof, and drugs containing said derivatives RHONE-POULENC RORER S.A. (FR) 1999-05-11 US disclosed
EP-0820455-A1 5H, 10H-IMIDAZO [1,2-a]INDENO [1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES Aventis Pharma S.A. (FR) 1998-01-28 EP disclosed
WO-1996031511-A1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZIN-4-ONE DERIVATIVES, PREPARATION THEREOF, AND DRUGS CONTAINING SAID DERIVATIVES RHONE-POULENC RORER S.A. (FR) 1996-10-10 WO disclosed