Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7833737 | 0.88 | MEN1 (0.65) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL6222546 | 0.80 | RAB9A (0.60) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL7832027 | 0.80 | LMNA (0.49) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL7826384 | 0.80 | KDM4E (0.51) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL7830618 | 0.80 | RAB9A (0.52) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL9068246 | 0.79 | RAB9A (0.49) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL4557117 | 0.78 | GRM5 (0.52) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL9447009 | 0.77 | KMT2A (0.77) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL7820255 | 0.77 | MAPT (0.62) | MEN1KMT2ANPC1MAPTKDM4E | |
| SCHEMBL7819492 | 0.77 | RAB9A (0.44) | MEN1KMT2ANPC1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764165-B1 | PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | EP | claimed |
| US-5346911-A | Analgesics, cognition activators, treatment of alzheimer*s s disease | WARNER-LAMBERT COMPANY (US) | 1994-09-13 | — | — | US | claimed |
| EP-0764165-B1 | PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5514812-A | Preparation of stereochemically pure oximes with muscarinic activity | WARNER-LAMBERT COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5346911-A | Analgesics, cognition activators, treatment of alzheimer*s s disease | WARNER-LAMBERT COMPANY (US) | 1994-09-13 | — | — | US | disclosed |