Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7819953 | 0.88 | MEN1 (0.56) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL7820036 | 0.82 | RAB9A (0.59) | MEN1KMT2ANPC1MAPTGAA | |
| SCHEMBL6222546 | 0.82 | RAB9A (0.60) | MEN1KMT2ANPC1MAPTGAA | |
| SCHEMBL7830964 | 0.81 | MAPT (0.50) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL7819253 | 0.81 | LMNA (0.50) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL7820076 | 0.79 | KDM4E (0.56) | MEN1KMT2ANPC1MAPTHTT | |
| SCHEMBL6217256 | 0.79 | MAPT (0.50) | MEN1KMT2ANPC1MAPTGAA | |
| SCHEMBL9068246 | 0.79 | RAB9A (0.49) | MEN1KMT2ANPC1MAPTGAA | |
| SCHEMBL1083102 | 0.79 | MEN1 (1.00) | MEN1KMT2ANPC1MAPTALDH1A1 | |
| SCHEMBL7831393 | 0.78 | RAB9A (0.46) | MEN1KMT2ANPC1MAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764165-B1 | PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | EP | claimed |
| US-5346911-A | Analgesics, cognition activators, treatment of alzheimer*s s disease | WARNER-LAMBERT COMPANY (US) | 1994-09-13 | — | — | US | claimed |
| EP-0764165-B1 | PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY | WARNER LAMBERT CO (US) | 2001-11-07 | — | — | EP | disclosed |
| US-5514812-A | Preparation of stereochemically pure oximes with muscarinic activity | WARNER-LAMBERT COMPANY (US) | 1996-05-07 | — | — | US | disclosed |
| US-5346911-A | Analgesics, cognition activators, treatment of alzheimer*s s disease | WARNER-LAMBERT COMPANY (US) | 1994-09-13 | — | — | US | disclosed |