Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820028 | 0.80 | CRHR1 (0.34) | CRHR1MAPTALDH1A1MAPK1EDNRB | |
| SCHEMBL6775364 | 0.74 | ALOX15 (0.35) | ALOX15ALOX12PIK3CAMTOR | |
| SCHEMBL3102887 | 0.69 | MAPT (0.40) | MAPTALDH1A1PIN1S1PR4GRIN2D | |
| SCHEMBL7827120 | 0.67 | TLR7 (0.35) | CRHR1PIK3CAMTOR | |
| SCHEMBL7944720 | 0.66 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL6781376 | 0.65 | MEN1 (0.39) | CRHR1ALDH1A1MAPK1HPGDTDP1 | |
| SCHEMBL6780509 | 0.65 | MEN1 (0.39) | CRHR1ALDH1A1MAPK1HPGDTDP1 | |
| SCHEMBL6889787 | 0.64 | CRHR1 (0.42) | CRHR1MAPK1TSHRALOX15PIK3CA | |
| SCHEMBL6774956 | 0.64 | CRHR1 (0.39) | CRHR1ALOX15ALOX12 | |
| SCHEMBL6775008 | 0.63 | CRHR1 (0.47) | CRHR1MAPTALDH1A1MAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901476-A4 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DU PONT PHARM CO (US) | 2001-08-16 | — | — | EP | claimed |
| EP-0901476-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | Du Pont Pharmaceuticals Company (US) | 1999-03-17 | — | — | EP | claimed |
| WO-1997035846-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DUPONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | claimed |
| EP-0901476-A4 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DU PONT PHARM CO (US) | 2001-08-16 | — | — | EP | disclosed |
| US-6258809-B1 | NERVOUS SYSTEM DISORDERS, ANTIDEPRESSANTS AND PSYCHIATRY | DUPONT PHARMACEUTICALS COMPANY | 2001-07-10 | — | — | US | disclosed |
| US-6124300-A | Aryloxy- and arylthio- fused pyridines and pyrimidines and derivatives | DUPONT PHARMACEUTICALS (US) | 2000-09-26 | — | — | US | disclosed |
| EP-0901476-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | Du Pont Pharmaceuticals Company (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997035846-A1 | ARYLOXY- AND ARYLTHIO-FUSED PYRIDINES AND PYRIMIDINES AND DERIVATIVES | DUPONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | disclosed |