Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 2/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24299044 | 0.89 | ALDH1A1 (0.69) | ALDH1A1HSD17B10RAB9ACYP2C19TSHR | |
| SCHEMBL3011694 | 0.89 | RAB9A (0.66) | ALDH1A1HSD17B10RAB9ACYP2C19TSHR | |
| SCHEMBL3446280 | 0.89 | GAA (0.69) | ALDH1A1HSD17B10RAB9ACYP2C19TSHR | |
| SCHEMBL20406919 | 0.88 | RAB9A (0.64) | ALDH1A1HSD17B10RAB9ACYP2C19TSHR | |
| SCHEMBL1865430 | 0.87 | ALDH1A1 (0.60) | ALDH1A1HSD17B10RAB9ACYP2C19TSHR | |
| SCHEMBL9949471 | 0.80 | TSHR (0.55) | ALDH1A1HSD17B10CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL21670259 | 0.80 | TSHR (0.58) | ALDH1A1HSD17B10CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL12455605 | 0.80 | TSHR (0.58) | ALDH1A1HSD17B10CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL9949467 | 0.80 | TSHR (0.55) | ALDH1A1HSD17B10CYP2C19TSHRSMN1; SMN2 | |
| SCHEMBL24072673 | 0.80 | RAB9A (0.98) | ALDH1A1RAB9ACYP2C19TSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8202888-B2 | Piperidine sulphonamide derivatives | HOFFMANN-LA ROCHE INC. (US) | 2012-06-19 | — | — | US | disclosed |
| US-20090203736-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203736-A1 | PIPERIDINE SULPHONAMIDE DERIVATIVES | HCRTR2, PER2, HCRTR1 | ALDH1A1 477/4885HSD17B10 3019/4885RAB9A 2023/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.