Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 3/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.31 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.31 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.31 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834918 | 0.89 | LOXL2 (0.38) | PDE10ALOXL2KCNN3CRHR1 | |
| SCHEMBL7820734 | 0.89 | LOXL2 (0.48) | PDE10ALOXL2KCNN3PRKAB2PRKAG1 | |
| SCHEMBL7832772 | 0.84 | LOXL2 (0.35) | PDE10ALOXL2KCNN3PRKAB2PRKAG1 | |
| SCHEMBL7833319 | 0.83 | LOXL2 (0.46) | PDE10ALOXL2KCNN3 | |
| SCHEMBL7830196 | 0.82 | PDE10A (0.40) | PDE10ALOXL2KCNN3PRKAB2PRKAG1 | |
| SCHEMBL7831770 | 0.80 | PDE10A (0.43) | PDE10ALOXL2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7831474 | 0.78 | PDE10A (0.35) | PDE10ALOXL2KCNN3HPGD | |
| SCHEMBL7830192 | 0.78 | KCNN3 (0.40) | PDE10ALOXL2KCNN3CRHR1MAPKAPK2 | |
| SCHEMBL7833160 | 0.78 | PDE10A (0.41) | PDE10ALOXL2PRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7834964 | 0.78 | PDE10A (0.41) | PDE10ALOXL2PRKAB2PRKAG1PRKAA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |