Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.32 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.32 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.32 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.32 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.32 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.32 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.32 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.32 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.32 |
| ▸ | KCNN3 | Q9UGI6 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820735 | 0.84 | PDE10A (0.39) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7820734 | 0.83 | LOXL2 (0.48) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7834918 | 0.81 | LOXL2 (0.38) | LOXL2PDE10AKCNN3 | |
| SCHEMBL7833191 | 0.80 | PDE10A (0.36) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7831474 | 0.79 | PDE10A (0.35) | LOXL2PDE10AKCNN3MAPTHPGD | |
| SCHEMBL7833319 | 0.79 | LOXL2 (0.46) | LOXL2PDE10AKCNN3MAPT | |
| SCHEMBL7830192 | 0.79 | KCNN3 (0.40) | LOXL2PDE10AKCNN3 | |
| SCHEMBL7821057 | 0.77 | LOXL2 (0.37) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7829335 | 0.77 | PDE10A (0.38) | LOXL2PDE10APRKAB2PRKAG1PRKAA2 | |
| SCHEMBL7835702 | 0.76 | KCNN3 (0.39) | LOXL2PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820997-B1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMA CO LTD (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5985882-A | ANALGESICS | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1999-11-16 | — | — | US | disclosed |
| EP-0820997-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES | OTSUKA PHARMACEUTICAL FACTORY, INC. (JP) | 1998-01-28 | — | — | EP | disclosed |