SCHEMBL648157

SCHEMBL648157

Cc1cc(/C=N\O)ccc1Br

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.46
KDM4E B2RXH2 4/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
SMN1; SMN2 Q16637 3/20 0.43
RAB9A P51151 2/20 0.43
NPFFR1 Q9GZQ6 3/20 0.41
NPFFR2 Q9Y5X5 3/20 0.41
HTT P42858 3/20 0.39
GAA P10253 3/20 0.39
MAPK1 P28482 2/20 0.38
KMT2A Q03164 2/20 0.38
ACHE P22303 1/20 0.38
POLB P06746 2/20 0.37
JAK2 O60674 1/20 0.37
MAPT P10636 1/20 0.37
HPGD P15428 1/20 0.37
ALOX12 P18054 1/20 0.37
HSD17B10 Q99714 1/20 0.37
PKM P14618 1/20 0.37
MEN1 O00255 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL111119 1.00 ALDH1A1 (0.46) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL113975 1.00 ALDH1A1 (0.46) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL1304437 0.86 SMN1; SMN2 (0.47) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL1304439 0.86 SMN1; SMN2 (0.47) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL2726909 0.86 SMN1; SMN2 (0.47) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL7820864 0.82 ALDH1A1 (0.39) ALDH1A1KDM4ESMN1; SMN2RAB9ANPFFR1
SCHEMBL7820867 0.82 ALDH1A1 (0.39) ALDH1A1KDM4ESMN1; SMN2RAB9ANPFFR1
SCHEMBL1937076 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL2166114 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A
SCHEMBL1937074 0.81 ALDH1A1 (0.50) ALDH1A1KDM4EL3MBTL1SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2023-11-09 US disclosed
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-12-29 US disclosed
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2020-05-21 US disclosed
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL CORPORATION (JP) 2020-03-24 US disclosed
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-11-08 US disclosed
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-03-09 US disclosed
US-20150105398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL CORPORATION (JP) 2015-04-16 US disclosed
US-8987464-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-03-24 US disclosed
US-8946492-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2015-02-03 US disclosed
US-20140135496-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-05-15 US disclosed
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-10-13 US disclosed
US-8022089-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-09-20 US disclosed
US-20110144334-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-06-16 US disclosed
US-7951828-B1 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2011-05-31 US disclosed
US-20100144797-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-06-10 US disclosed
US-7662972-B2 Isoxazoline-substituted benzamide compound and pesticide NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-02-16 US disclosed
EP-2151437-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2010-02-10 EP disclosed
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2009-12-17 US disclosed
EP-1932836-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND HARMFUL ORGANISM-CONTROLLING AGENT Nissan Chemical Industries, Ltd. (JP) 2008-06-18 EP disclosed
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2007-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110144334-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE OR10J3, OR51E2, ORMDL3 ALDH1A1 475/4885KDM4E 3581/4885L3MBTL1 882/4885
US-20150105398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ALDH1A1 3263/4885KDM4E 3394/4885L3MBTL1 297/4885
US-20230355590-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE HDAC7, ACHE, BRDT ALDH1A1 865/4885KDM4E 1334/4885L3MBTL1 2698/4885
US-10596157-B2 Isoxazoline-substituted benzamide compound and pesticide CHRM3, C3AR1, C9 ALDH1A1 3052/4885KDM4E 3243/4885L3MBTL1 187/4885
US-20180318266-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CHRM3, C3AR1, C9 ALDH1A1 3052/4885KDM4E 3243/4885L3MBTL1 187/4885
US-20100144797-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PEST CONTROL AGENT H1-2, H1-0, H1-3 ALDH1A1 815/4885KDM4E 1095/4885L3MBTL1 208/4885
US-20090312330-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE ATM, CHRM1, NAT1 ALDH1A1 806/4885KDM4E 3394/4885L3MBTL1 818/4885
US-10874645-B2 Isoxazoline-substituted benzamide compound and pesticide C3AR1, C5, C9 ALDH1A1 3404/4885KDM4E 3177/4885L3MBTL1 278/4885
US-20140135496-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE OR10J3, OR51E2, ODC1 ALDH1A1 988/4885KDM4E 4132/4885L3MBTL1 950/4885
US-20110251398-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE CBR3, CHRM1, CBR1 ALDH1A1 1983/4885KDM4E 4330/4885L3MBTL1 910/4885
US-20170065565-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ALDH1A1 3048/4885KDM4E 3394/4885L3MBTL1 243/4885
US-20070066617-A1 Insecticidal and acaricidal activity for many agricultural insect pests, spider mites; endo- or ecto-parasiticide for mammals or birds; veterinary medicine; environmentally friendly CHRM1, DDT, ATM ALDH1A1 1359/4885KDM4E 3630/4885L3MBTL1 200/4885
US-20200155511-A1 ISOXAZOLINE-SUBSTITUTED BENZAMIDE COMPOUND AND PESTICIDE C3AR1, C5, C9 ALDH1A1 3404/4885KDM4E 3177/4885L3MBTL1 278/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.