Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8573566 | 0.82 | RAB9A (0.50) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL13462878 | 0.81 | SMN1; SMN2 (0.58) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL574545 | 0.79 | RAB9A (0.48) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL6664950 | 0.79 | SMN1; SMN2 (0.56) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL32683597 | 0.78 | RAB9A (0.47) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL573504 | 0.78 | KMT2A (0.48) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL32683716 | 0.77 | KMT2A (0.47) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL3509334 | 0.77 | SMN1; SMN2 (0.54) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL19210051 | 0.76 | KMT2A (0.46) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL13887500 | 0.76 | LMNA (0.49) | RAB9ANPC1KDM4EKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1123296-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Pfizer Limited (GB) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024745-A1 | PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION | PFIZER LIMITED (GB) | 2000-05-04 | — | — | WO | disclosed |