Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 13/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7830739 | 0.80 | PDPK1 (0.41) | POLA1PDPK1GDAADORA3ADORA1 | |
| Hydrochloric Acid SCHEMBL7832921 | 0.79 | PDPK1 (0.40) | POLA1PDPK1GDAADORA3ADORA1 | |
| SCHEMBL7821784 | 0.79 | ALDH1A1 (0.42) | POLA1MEN1NPC1ALDH1A1TP53 | |
| SCHEMBL7830814 | 0.77 | NEK2 (0.48) | PDPK1GDAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7833385 | 0.76 | MPO (0.45) | POLA1PDPK1GDA | |
| Hydrochloric Acid SCHEMBL7833212 | 0.76 | NEK2 (0.48) | PDPK1GDAALDH1A1MAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7834487 | 0.75 | MPO (0.44) | POLA1PDPK1GDA | |
| SCHEMBL1741361 | 0.74 | ADORA3 (0.69) | PDPK1GDAADORA3ADORA1ADORA2A | |
| SCHEMBL29791254 | 0.74 | ADORA3 (0.69) | PDPK1GDAADORA3ADORA1ADORA2A | |
| SCHEMBL7249956 | 0.73 | BRAF (0.50) | PDPK1GDAADORA3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | claimed |
| EP-0802914-B1 | ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES | PHARMACIA & UPJOHN SPA (IT) | 2001-06-06 | — | — | EP | disclosed |