Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 11/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | KMO | O15229 | 1/20 | 0.45 |
| ▸ | CDK4 | P11802 | 2/20 | 0.44 |
| ▸ | CCND1 | P24385 | 2/20 | 0.44 |
| ▸ | TERT | O14746 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7834050 | 1.00 | P2RX7 (0.51) | P2RX7TBXAS1MGLLKMOCDK4 | |
| SCHEMBL7831871 | 0.99 | P2RX7 (0.52) | P2RX7TBXAS1MGLLKMOCDK4 | |
| SCHEMBL2127960 | 0.88 | KMO (0.56) | P2RX7TBXAS1KMO | |
| SCHEMBL7836228 | 0.82 | TNF (0.51) | P2RX7TBXAS1MGLL | |
| SCHEMBL21245260 | 0.80 | P2RX7 (0.52) | P2RX7MGLLCDK4CCND1 | |
| SCHEMBL30582936 | 0.80 | CDK4 (0.72) | CDK4CCND1TERT | |
| SCHEMBL19783673 | 0.80 | CDK4 (0.72) | CDK4CCND1TERT | |
| SCHEMBL112058 | 0.79 | KMT2A (0.60) | P2RX7KMO | |
| SCHEMBL1269116 | 0.78 | CDK4 (0.71) | CDK4CCND1TERT | |
| SCHEMBL10469109 | 0.77 | EGLN3 (0.52) | TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668279-B1 | 6-Azaindole thromboxane synthase inhibitors | LILLY CO ELI (US) | 2001-06-13 | — | — | EP | claimed |
| US-5468757-A | FOR TREATING STROKE OR MYOCARDIAL INFARCTION IN HUMANS | ELI LILLY AND COMPANY (US) | 1995-11-21 | — | — | US | claimed |
| EP-0668279-A2 | 6-Azaindole thromboxane synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-23 | — | — | EP | claimed |
| EP-0668279-B1 | 6-Azaindole thromboxane synthase inhibitors | LILLY CO ELI (US) | 2001-06-13 | — | — | EP | disclosed |
| US-5468757-A | FOR TREATING STROKE OR MYOCARDIAL INFARCTION IN HUMANS | ELI LILLY AND COMPANY (US) | 1995-11-21 | — | — | US | disclosed |
| EP-0668279-A2 | 6-Azaindole thromboxane synthase inhibitors | ELI LILLY AND COMPANY (US) | 1995-08-23 | — | — | EP | disclosed |