Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7825789 | 0.82 | CSNK2A1 (0.40) | ALDH1A1KDM4EHPGDCYP3A4ACHE | |
| SCHEMBL7592279 | 0.81 | SMN1; SMN2 (0.38) | GAAALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7470942 | 0.72 | L3MBTL1 (0.37) | GAAALDH1A1KDM4EHPGDACHE | |
| SCHEMBL7810829 | 0.72 | NQO2 (0.33) | POLB | |
| SCHEMBL7468982 | 0.71 | ALDH1A1 (0.45) | GAAALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL22690002 | 0.69 | POLB (0.50) | GAAALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7811964 | 0.69 | NQO2 (0.33) | POLB | |
| SCHEMBL7472004 | 0.69 | ALDH1A1 (0.36) | GAAALDH1A1KDM4EHPGDCYP3A4 | |
| SCHEMBL7598494 | 0.68 | KMT2A (0.38) | ALDH1A1CYP3A4POLBMEN1KMT2A | |
| SCHEMBL27459361 | 0.68 | NQO2 (0.48) | GAAALDH1A1KDM4ECYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0781279-B1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | PFIZER LTD (GB) | 2001-06-13 | — | — | EP | disclosed |
| US-5783572-A | TREATMENT OF NEURODEGENERATIVE DISORDERS | PFIZER INC. (US) | 1998-07-21 | — | — | US | disclosed |
| EP-0781279-A1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | Pfizer Limited (GB) | 1997-07-02 | — | — | EP | disclosed |
| WO-1996008485-A1 | QUINOXALINEDIONE NMDA RECEPTOR ANTAGONISTS | PFIZER LIMITED (GB) | 1996-03-21 | — | — | WO | disclosed |