Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.69 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 3/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | PRKCB | P05771 | 5/20 | 0.45 |
| ▸ | PRKCA | P17252 | 5/20 | 0.45 |
| ▸ | PRKCH | P24723 | 5/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 5/20 | 0.45 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.45 |
| ▸ | CDK4 | P11802 | 3/20 | 0.45 |
| ▸ | CCND1 | P24385 | 3/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.45 |
| ▸ | PRKACA | P17612 | 2/20 | 0.45 |
| ▸ | PRKACG | P22612 | 2/20 | 0.45 |
| ▸ | PRKACB | P22694 | 2/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827326 | 0.85 | PDGFRB (0.50) | SIRT2SIRT1PDGFRBPIM1PRKCB | |
| SCHEMBL7815818 | 0.84 | PRKCB (0.67) | SIRT2PDGFRBPIM1PRKCBPRKCA | |
| SCHEMBL3945882 | 0.83 | SIRT2 (1.00) | SIRT2SIRT1RPS6KB1PIM1CCNT1 | |
| SCHEMBL30958473 | 0.83 | SIRT2 (1.00) | SIRT2SIRT1RPS6KB1PIM1CCNT1 | |
| SCHEMBL7825953 | 0.78 | SIRT2 (0.72) | SIRT2SIRT1RPS6KB1PDGFRBPIM1 | |
| SCHEMBL8354590 | 0.78 | SIRT2 (0.76) | SIRT2SIRT1RPS6KB1PDGFRBPIM1 | |
| SCHEMBL5334741 | 0.75 | SIRT2 (0.67) | SIRT2SIRT1RPS6KB1PIM1CCNT1 | |
| SCHEMBL7504252 | 0.74 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PIM1CCNT1 | |
| SCHEMBL5682604 | 0.74 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PIM1CCNT1 | |
| SCHEMBL5343477 | 0.74 | SIRT2 (0.80) | SIRT2SIRT1RPS6KB1PIM1CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397060-B1 | Maleinimide derivatives and their use as medicines | GOEDECKE AG (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-5516915-A | Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |