Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 12/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782610 | 0.89 | EDNRA (0.39) | PTGS2HSD11B1EDNRBEDNRAMEN1 | |
| SCHEMBL782600 | 0.88 | EDNRA (0.40) | PTGS2KDM4EHSD11B1EDNRASMN1; SMN2 | |
| SCHEMBL782599 | 0.88 | PTGS2 (0.39) | PTGS2 | |
| SCHEMBL782234 | 0.88 | EDNRA (0.44) | KDM4EEDNRBEDNRAHTT | |
| SCHEMBL782249 | 0.82 | CYP19A1 (0.45) | KDM4EEDNRBEDNRAMEN1KMT2A | |
| SCHEMBL782401 | 0.82 | EDNRA (0.43) | PTGS2EDNRBEDNRASMN1; SMN2LMNA | |
| SCHEMBL782459 | 0.81 | — | — | |
| SCHEMBL782477 | 0.80 | NPY5R (0.31) | — | |
| SCHEMBL13548002 | 0.80 | PTGS2 (0.39) | PTGS2KDM4EMEN1NPC1RAB9A | |
| SCHEMBL782373 | 0.80 | NPY5R (0.39) | HSD11B1NPC1RAB9ASMN1; SMN2HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8574607-B2 | Spiroheterocyclic thiofuran dione derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8574607-B2 | Spiroheterocyclic thiofuran dione derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| WO-2012069008-A1 | 3-SUBSTITUTED SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES USEFUL AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | DDT, DHFR, CYP1A1 | PTGS2 1260/4885KDM4E 3621/4885HSD11B1 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.