Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.44 |
| ▸ | EDNRB | P24530 | 1/20 | 0.44 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
| ▸ | ME1 | P48163 | 1/20 | 0.42 |
| ▸ | ME3 | Q16798 | 1/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL782610 | 0.89 | EDNRA (0.39) | EDNRAEDNRBNPY5RPTGS1ALDH1A1 | |
| SCHEMBL782600 | 0.88 | EDNRA (0.40) | EDNRANPY5RKDM4E | |
| SCHEMBL782377 | 0.88 | PTGS2 (0.39) | EDNRAEDNRBHTTKDM4E | |
| SCHEMBL782599 | 0.88 | PTGS2 (0.39) | NPY5RDRD2SIGMAR1PTGS1 | |
| SCHEMBL782249 | 0.84 | CYP19A1 (0.45) | EDNRAEDNRBALDH1A1GSK3BKDM4E | |
| SCHEMBL13548121 | 0.83 | ALDH1A1 (0.47) | EDNRAEDNRBME2ME1ME3 | |
| SCHEMBL782401 | 0.82 | EDNRA (0.43) | EDNRAEDNRBPTGS1ALDH1A1 | |
| SCHEMBL782257 | 0.82 | AVPR1A (0.39) | EDNRAEDNRBNPY5RKDM4E | |
| SCHEMBL782237 | 0.82 | CHEK1 (0.38) | EDNRAEDNRBPTGS1ALDH1A1MAOB | |
| SCHEMBL782477 | 0.80 | NPY5R (0.31) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8574607-B2 | Spiroheterocyclic thiofuran dione derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8574607-B2 | Spiroheterocyclic thiofuran dione derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| WO-2012069008-A1 | 3-SUBSTITUTED SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES USEFUL AS PESTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071319-A1 | SPIROHETEROCYCLIC FURAN AND THIOFURAN DIONE DERIVATIVES | DDT, DHFR, CYP1A1 | EDNRA 2764/4885EDNRB 4102/4885ME2 3079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.