Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755770 | 0.76 | GRM5 (0.39) | GRM5HTR7FFAR1GRIA1GRIA3 | |
| SCHEMBL6767423 | 0.76 | GRIA1 (0.37) | GRM5KDM4EFFAR1GRIA1GRIA3 | |
| SCHEMBL18411456 | 0.68 | KDM4E (0.52) | GRM5KDM4EFFAR1GRIA1GRIA3 | |
| SCHEMBL27581432 | 0.68 | GRIA1 (0.39) | GRM5KDM4EGRIA1GRIA3PDE4D | |
| SCHEMBL27580424 | 0.68 | MEN1 (0.39) | GRM5KDM4EFFAR1GRIA1GRIA3 | |
| Dipyridyl SCHEMBL27792926 | 0.67 | KDM4E (0.64) | GRM5KDM4EFFAR1GRIA1GRIA3 | |
| SCHEMBL27861663 | 0.66 | GRIA1 (0.39) | GRM5KDM4EGRIA1GRIA3PDE4D | |
| SCHEMBL11374854 | 0.65 | ABL1 (0.40) | GRM5KDM4EDRD2PHGDH | |
| SCHEMBL30794908 | 0.65 | GRM5 (0.58) | GRM5KDM4EGRIA1GRIA3PDE4D | |
| SCHEMBL2363575 | 0.65 | TSHR (0.52) | GRM5KDM4EFFAR1GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1153922-A1 | HETERODIAZINONE DERIVATIVES | Eisai Co., Ltd. (JP) | 2001-11-14 | — | — | EP | disclosed |