Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | BCL6 | P41182 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5779088 | 0.83 | KMT2A (0.40) | KDM4EMEN1KMT2A | |
| SCHEMBL5778171 | 0.81 | MEN1 (0.39) | SLC5A2KDM4ESLC5A1MEN1HTT | |
| SCHEMBL6763399 | 0.81 | HTR7 (0.35) | SLC5A2KDM4ESLC5A1MEN1KMT2A | |
| SCHEMBL5780049 | 0.81 | SLC5A2 (0.36) | SLC5A2KDM4ESLC5A1PKMMEN1 | |
| SCHEMBL6763497 | 0.79 | PDCD1 (0.42) | KDM4EPKMMEN1HTTKMT2A | |
| SCHEMBL5778501 | 0.78 | MAPT (0.42) | GRM5KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5780693 | 0.77 | MAPT (0.41) | GRM5KDM4EMEN1KMT2A | |
| SCHEMBL7824017 | 0.76 | GRM5 (0.38) | GRIA1GRIA3PDE4DGRM5KDM4E | |
| SCHEMBL6767437 | 0.75 | MAPK14 (0.36) | SLC5A2KDM4EFFAR1SLC5A1KMT2A | |
| SCHEMBL5782501 | 0.75 | GRM5 (0.43) | GRM5KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825192-B1 | NON-N-METHYL-D-ASPARTATE (NON- NMDA) EXCITATORY AMINO ACID RECEPTOR ANTAGONISTIC ACTION, FOR EXAMPLE 2-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLE PROPIONIC ACID (AMPA) RECEPTOR ANTAGONISTIC ACTION | EISAI CO., LTD. (JP) | 2004-11-30 | — | — | US | disclosed |