Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.37 |
| ▸ | NQO2 | P16083 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1115295 | 0.93 | ALDH1A1 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7824882 | 0.87 | GRIN2D (0.44) | KDM4EALDH1A1HPGDGRIN2DGRIN3B | |
| SCHEMBL8057885 | 0.85 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL8057429 | 0.85 | ALDH1A1 (0.41) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL8067979 | 0.82 | DAO (0.39) | KDM4EALDH1A1HPGDGRIN2DGRIN3B | |
| SCHEMBL8067091 | 0.82 | ULK1 (0.34) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7829950 | 0.80 | DYRK1A (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2MAPT | |
| SCHEMBL8068038 | 0.80 | CYP19A1 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2GRIN2D | |
| SCHEMBL7826292 | 0.80 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL8069105 | 0.79 | POLB (0.42) | KDM4EALDH1A1HPGDMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |