Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | HTR1A | P08908 | 8/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7817703 | 0.98 | HTR2A (0.43) | HTR2AHTR1ASLC6A4MTNR1ACYP1A2 | |
| SCHEMBL7825966 | 0.88 | MPO (0.42) | HTR1ASLC6A4MPO | |
| SCHEMBL7817353 | 0.86 | SLC6A4 (0.46) | HTR1ASLC6A4KDM4EMEN1KMT2A | |
| SCHEMBL7817710 | 0.86 | HTR1A (0.36) | HTR2AHTR1ASLC6A4KDM4EMEN1 | |
| SCHEMBL7817689 | 0.85 | HTR2C (0.39) | HTR2AHTR1ASLC6A4CYP1A2CYP2D6 | |
| SCHEMBL7818121 | 0.85 | MPO (0.45) | HTR1ASLC6A4MPO | |
| SCHEMBL7828217 | 0.83 | HTR1A (0.39) | HTR2AHTR1ASLC6A4KDM4EMEN1 | |
| SCHEMBL1322750 | 0.76 | SLC6A4 (0.33) | SLC6A4 | |
| SCHEMBL8694687 | 0.74 | HTR2B (0.38) | HTR2AHTR1AMTNR1ACYP1A2CYP2D6 | |
| SCHEMBL8690809 | 0.74 | HTR2B (0.38) | HTR2AHTR1AMTNR1ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | claimed |
| EP-0861248-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-02 | — | — | EP | claimed |
| WO-1997017343-A1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-15 | — | — | WO | claimed |
| EP-0861248-B1 | INDOLEALKYL DERIVATIVES OF BENZODIOXANMETHYLAMINE AS 5-HT1A RECEPTOR LIGANDS | AMERICAN HOME PROD (US) | 2001-12-12 | — | — | EP | disclosed |