Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18128350 | 0.85 | CRHBP (0.49) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL7014583 | 0.78 | CA12 (0.42) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL28813437 | 0.76 | KMT2A (0.41) | MEN1KMT2AL3MBTL1SMN1; SMN2POLB | |
| SCHEMBL30717957 | 0.76 | L3MBTL1 (0.45) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL4852951 | 0.76 | CRHBP (0.44) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL28379977 | 0.75 | L3MBTL1 (0.36) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL27087987 | 0.75 | MEN1 (0.38) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL8694142 | 0.75 | ALDH1A1 (0.40) | CRHBPCRHR2TSHRMEN1KMT2A | |
| SCHEMBL7826717 | 0.74 | KMT2A (0.44) | TSHRMEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL27036991 | 0.74 | AKR1C3 (0.50) | MEN1KMT2AALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745081-B1 | INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 2001-11-21 | — | — | EP | disclosed |
| EP-0656001-B1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMA INC (US) | 1999-09-15 | — | — | EP | disclosed |
| EP-0534363-B1 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5604221-A | Indane-2-mercaptoacetylamide disulfide derivatives useful as inhibitors of enkephalinase | MERRELL PHARMACEUTICALS INC. (US) | 1997-02-18 | — | — | US | disclosed |
| US-5591739-A | 2-substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ACE | MERRELL PHARMACEUTICALS INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0745081-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1996-12-04 | — | — | EP | disclosed |
| EP-0534396-B1 | 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMA INC (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5529996-A | USEFUL FOR CONGESTIVE HEART FAILURE, DIURETIC EFFECT, IRRITABLE BOWL MOVEMENT, ENDORPHIN OR ENKEPHALIN MEDIATED ANALGESIC EFFECTS AND ALSO HYPOTENSIVE AGENT | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-06-25 | — | — | US | disclosed |
| US-5491142-A | 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5491141-A | ENZYME INHIBITORS, HYPERTENSIVE AGENTS; TREATING DIURETIC, CONGESTIVE HEART FAILURE, ALDOSTERONISM, RENAL DISEASES, GLAUCOMA | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-02-13 | — | — | US | disclosed |
| US-5486513-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors or enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-01-23 | — | — | US | disclosed |
| US-5457196-A | Analgesics, hypotensive agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995021840-A1 | NOVEL INDANE-2-MERCAPTOACETYLAMIDE DISULFIDE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-08-17 | — | — | WO | disclosed |
| US-5428158-A | 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-06-27 | — | — | US | disclosed |
| EP-0656001-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-07 | — | — | EP | disclosed |
| US-5420271-A | Analgesics, cardiovascular disorders, diuretics or hypoaldosteronemic agents | MERRELL DOW PHARMACEUTICALS, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| WO-1994004531-A1 | NOVEL 2-SUBSTITUTED INDANE-2-MERCAPTOACETYLAMIDE TRICYCLIC DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-03 | — | — | WO | disclosed |
| EP-0534396-A2 | 2-Substituted indane-2-carboxyalkyl derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0534363-A2 | Novel 2-substituted indane-2-mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace | MERRELL PHARMACEUTICALS INC. (US) | 1993-03-31 | — | — | EP | disclosed |