SCHEMBL7825161

SCHEMBL7825161

Cc1c(Cl)cccc1NC(=O)c1ccccc1C(=O)O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.68
CYP1A2 P05177 2/20 0.68
HPGD P15428 2/20 0.68
CYP2C19 P33261 2/20 0.68
KMT2A Q03164 2/20 0.68
MEN1 O00255 1/20 0.68
USP2 O75604 1/20 0.68
MT-CO2 P00403 1/20 0.68
LMNA P02545 1/20 0.68
TTR P02766 1/20 0.68
PLA2G1B P04054 1/20 0.68
PGR P06401 1/20 0.68
CYP3A4 P08684 1/20 0.68
HTR1A P08908 1/20 0.68
ADRA2A P08913 1/20 0.68
ADORA3 P0DMS8 1/20 0.68
AR P10275 1/20 0.68
CYP2C9 P11712 1/20 0.68
HTR2A P28223 1/20 0.68
ADRA1A P35348 1/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2700280 0.85 CYP1A2 (0.77) MAPTCYP1A2HPGDCYP2C19KMT2A
SCHEMBL29168828 0.85 MAPT (0.65) MAPTCYP1A2HPGDCYP2C19KMT2A
SCHEMBL29438754 0.84 NPC1 (0.72) CYP1A2HPGDKMT2AMEN1LMNA
SCHEMBL18844993 0.82 MAPT (0.62) MAPTCYP1A2HPGDCYP2C19KMT2A
SCHEMBL17374927 0.82 MAPT (0.61) MAPTCYP1A2HPGDCYP2C19KMT2A
Tolfenamic Acid SCHEMBL25190 0.81 MT-CO2 (1.00) MAPTCYP1A2HPGDCYP2C19KMT2A
Tolfenamic Acid SCHEMBL8060884 0.81 MT-CO2 (1.00) MAPTCYP1A2HPGDCYP2C19KMT2A
Tolfenamic Acid SCHEMBL29389998 0.81 MT-CO2 (1.00) MAPTCYP1A2HPGDCYP2C19KMT2A
Tolfenamic Acid SCHEMBL29484181 0.81 MT-CO2 (1.00) MAPTCYP1A2HPGDCYP2C19KMT2A
Iodide SCHEMBL30758631 0.81 MAPT (0.84) MAPTCYP1A2HPGDCYP2C19KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1091958-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2001-04-18 EP disclosed
WO-2000001692-A1 SALTS OF PAROXETINE SMITHKLINE BEECHAM PLC (GB) 2000-01-13 WO disclosed