Tolfenamic Acid

Tolfenamic Acid

SCHEMBL29389998

Cc1c(Cl)cccc1Nc1ccccc1C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MT-CO2 P00403 8/20 1.00
PTGS2 P35354 5/20 1.00
MEN1 O00255 3/20 1.00
AKR1C3 P42330 3/20 1.00
KMT2A Q03164 3/20 1.00
LMNA P02545 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP3A4 P08684 2/20 1.00
CYP2C9 P11712 2/20 1.00
HIF1A Q16665 2/20 1.00
TTR P02766 2/20 1.00
ADORA3 P0DMS8 2/20 1.00
USP2 O75604 1/20 1.00
PLA2G1B P04054 1/20 1.00
PGR P06401 1/20 1.00
HTR1A P08908 1/20 1.00
ADRA2A P08913 1/20 1.00
AR P10275 1/20 1.00
MAPT P10636 1/20 1.00
HPGD P15428 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tolfenamic Acid SCHEMBL8060884 1.00 MT-CO2 (1.00) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL25190 1.00 MT-CO2 (1.00) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL29484181 1.00 MT-CO2 (1.00) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL27540385 0.98 MT-CO2 (0.97) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL10619715 0.94 MT-CO2 (0.89) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL28095333 0.93 MT-CO2 (0.86) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL28229025 0.90 MT-CO2 (0.82) MT-CO2PTGS2MEN1AKR1C3KMT2A
Tolfenamic Acid SCHEMBL14976730 0.90 MT-CO2 (0.82) MT-CO2PTGS2MEN1AKR1C3KMT2A
SCHEMBL11564152 0.88 MT-CO2 (0.78) MT-CO2PTGS2MEN1AKR1C3KMT2A
SCHEMBL12608896 0.87 MT-CO2 (0.77) MT-CO2PTGS2MEN1AKR1C3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023001045-A9 EXTERNAL ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF 上海椿安生物医药科技有限公司 2023-10-26 WO claimed
US-20260083751-A1 ALLOSTERIC MODULATORS OF ANDROGEN RECEPTOR COACTIVATOR RECRUITMENT FOR CRPC THERAPY UNIVERSITY OF PITTSBURGH – OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) 2026-03-26 US disclosed
US-12545750-B2 Method for the diimide hydrogenation of emulsified unsaturated polymers PARKER DANE K (US) 2026-02-10 US disclosed
US-12508227-B2 Dry powder compositions with magnesium stearate Aspeya US Inc. (US) 2025-12-30 US disclosed
US-20250295871-A1 AN INHALER COMPRISING A RETENTION ELEMENT Vectura Inc. (US) 2025-09-25 US disclosed
US-20250241922-A1 ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF COVAL BIOPHARMA (SHANGHAI)CO., LTD. (CN) 2025-07-31 US disclosed
US-20250241921-A1 ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF COVAL BIOPHARMA (SHANGHAI)CO., LTD. (CN) 2025-07-31 US disclosed
US-12343425-B2 Dry powder formulations for inhalation Aspeya US Inc. (US) 2025-07-01 US disclosed
US-12329899-B2 Dry powder inhaler and methods of use Aspeya US Inc. (US) 2025-06-17 US disclosed
EP-4561656-A1 AN INHALER COMPRISING A RETENTION ELEMENT Aspeya US Inc. (US) 2025-06-04 EP disclosed
US-20220262507-A1 PHARMACEUTICAL AND BIOLOGICAL AGENT DELIVERY SYSTEM HAVING BIOMETRIC DATA ACQUISITION AND MONITORING CAPABILITIES SUMNER BLUFFS LLC (US) 2022-08-18 US disclosed
CN-114891070-A Anthelmintic depsipeptide compounds 勃林格殷格翰动物保健美国公司 2022-08-12 CN disclosed
US-20220244263-A1 METHODS FOR TREATING SMALL CELL NEUROENDOCRINE AND RELATED CANCERS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2022-08-04 US disclosed
US-20220246263-A1 NEBULIZING DEVICES AND SYSTEMS HAVING BIOMETRIC DATA ACQUISITION AND MONITORING CAPABILITIES SUMNER BLUFFS LLC (US) 2022-08-04 US disclosed
EP-3107548-B1 DRY POWDER FORMULATIONS FOR INHALATION OTITOPIC INC (US) 2022-06-08 EP disclosed
US-20220168516-A1 PRODUCT DELIVERY DEVICES AND METHODS BREATHE RESTORE, INC. 2022-06-02 US disclosed
EP-3324975-B1 COMPOSITION COMPRISING A THERAPEUTIC AGENT AND A RESPIRATORY STIMULANT AND METHODS FOR THE USE THEREOF HSU JOHN (US) 2022-05-18 EP disclosed
WO-2022089614-A1 APPLICATION OF THYMIDINE DERIVATIVE IN PREPARATION OF DRUGS 上海岸阔医药科技有限公司 2022-05-05 WO disclosed
US-20220054479-A1 OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE ELYSIUM THERAPEUTICS, INC. 2022-02-24 US disclosed
US-20220040206-A1 DRY POWDER FORMULATIONS FOR INHALATION OTITOPIC INC (US) 2022-02-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250241921-A1 ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF JAK1, TNF, CYP4A11 MT-CO2 1289/4885PTGS2 37/4885MEN1 4000/4885
US-20220054479-A1 OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE OPRM1, OPRK1, OPRD1 MT-CO2 3732/4885PTGS2 1368/4885MEN1 4875/4885
US-12508227-B2 Dry powder compositions with magnesium stearate ACMSD, SARAF, TMCO1 MT-CO2 318/4885PTGS2 26/4885MEN1 2067/4885
US-12545750-B2 Method for the diimide hydrogenation of emulsified unsaturated polymers ALOX15, SOD1, ALOX12 MT-CO2 3002/4885PTGS2 188/4885MEN1 4509/4885
US-20260083751-A1 ALLOSTERIC MODULATORS OF ANDROGEN RECEPTOR COACTIVATOR RECRUITMENT FOR CRPC THERAPY AR, NCOA3, NR5A1 MT-CO2 1443/4885PTGS2 1563/4885MEN1 4600/4885
US-20250241922-A1 ANTI-INFLAMMATORY COUPLING COMPOUND DRUG, AND PREPARATION METHOD THEREFOR AND USE THEREOF JAK1, TNF, CYP4A11 MT-CO2 1289/4885PTGS2 37/4885MEN1 4000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.