SCHEMBL7825259

SCHEMBL7825259

COC(=O)c1ccc(CNC(C)=O)c(-n2cccc2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
NQO2 P16083 3/20 0.44
BDKRB1 P46663 1/20 0.43
ALDH1A1 P00352 5/20 0.42
LMNA P02545 2/20 0.42
SETDB1 Q15047 2/20 0.42
TAS1R3 Q7RTX0 1/20 0.40
TAS1R1 Q7RTX1 1/20 0.40
FBP1 P09467 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39
XDH P47989 1/20 0.39
CA9 Q16790 1/20 0.39
CA14 Q9ULX7 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7816615 0.83 ALDH1A1 (0.46) ALDH1A1LMNAFBP1SMN1; SMN2CA12
Guanidine SCHEMBL8705211 0.83 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19NQO2
SCHEMBL7816932 0.80 CYP1A2 (0.43) CYP1A2CYP3A4CYP2C9CYP2C19SETDB1
SCHEMBL8699298 0.79 NQO2 (0.46) CYP1A2CYP3A4CYP2C9CYP2C19NQO2
SCHEMBL7825760 0.79 KDM5A (0.45) ALDH1A1LMNAFBP1CA12CA1
SCHEMBL27469088 0.79 ALDH1A1 (0.59) ALDH1A1LMNAFBP1SMN1; SMN2CA12
SCHEMBL7830336 0.77 SLC9A1 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7823115 0.76 CA12 (0.59) CYP1A2CYP3A4CYP2C9CYP2C19ALDH1A1
SCHEMBL7827414 0.76 ALDH1A1 (0.53) CYP2C9ALDH1A1LMNAFBP1SMN1; SMN2
SCHEMBL8705215 0.76 NQO2 (0.45) CYP1A2CYP3A4CYP2C9CYP2C19NQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699185-B1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO (JP) 2001-09-05 EP disclosed
US-5824691-A CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-10-20 US disclosed
EP-0699185-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1996-03-06 EP disclosed
WO-1994026709-A1 GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-11-24 WO disclosed