Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SFN | P31947 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778505 | 0.89 | HPGD (0.50) | HSD17B10KMT2AMEN1LMNAMAPK1 | |
| SCHEMBL7836351 | 0.88 | RAB9A (0.42) | HSD17B10NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7837513 | 0.88 | NPC1 (0.38) | HSD17B10NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6783293 | 0.86 | HSD17B10 (0.54) | HSD17B10NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7825718 | 0.86 | TP53 (0.47) | KMT2AMEN1POLBALDH1A1TP53 | |
| SCHEMBL7339157 | 0.85 | TACR1 (0.44) | NPC1RAB9AKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7340345 | 0.85 | TP53 (0.39) | NPC1RAB9ALMNATP53 | |
| SCHEMBL7341105 | 0.85 | CTSL (0.46) | KMT2AMEN1ALDH1A1TP53 | |
| SCHEMBL7341748 | 0.85 | TACR1 (0.41) | KMT2AMEN1POLBALDH1A1TP53 | |
| SCHEMBL7344058 | 0.84 | GLA (0.41) | NPC1RAB9AKMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |