Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | BCHE | P06276 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CDC25B | P30305 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | APAF1 | O14727 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL57213 | 0.74 | CA12 (0.42) | MAOACES1BCHEMAOBKMT2A | |
| SCHEMBL29824315 | 0.74 | CA12 (0.42) | MAOACES1BCHEMAOBKMT2A | |
| Hydrochloric Acid SCHEMBL7005883 | 0.72 | CA12 (0.41) | MAOACES1BCHEMAOBKMT2A | |
| SCHEMBL3099042 | 0.72 | CA12 (0.41) | MAOACES1BCHEMAOBKMT2A | |
| Hydrochloric Acid SCHEMBL2455497 | 0.72 | CA12 (0.41) | MAOACES1BCHEMAOBKMT2A | |
| SCHEMBL4771824 | 0.69 | MAOA (0.34) | MAOACES1BCHEL3MBTL1MAOB | |
| SCHEMBL7614336 | 0.69 | MAOA (0.33) | MAOACES1BCHEMAOBKMT2A | |
| SCHEMBL10640017 | 0.69 | ALDH1A1 (0.42) | MAOACES1BCHEL3MBTL1KMT2A | |
| SCHEMBL398908 | 0.65 | IDO1 (0.32) | — | |
| Acetamide SCHEMBL1668160 | 0.65 | ALDH1A1 (0.38) | MAOACES1TDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101962379-B | Method for refining sulfonyl isoquinoline derivative | SHANXI POWERDONE PHARMACEUTICS CO LTD | 2013-02-27 | — | — | CN | claimed |
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | claimed |
| EP-0187371-B1 | SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-06-19 | — | — | EP | claimed |
| JP-7118236-A | — | — | None | — | — | JP | disclosed |
| CN-112010805-B | Refining method of fasudil hydrochloride | 山东威高药业股份有限公司 | 2023-12-05 | — | — | CN | disclosed |
| CN-109705096-B | Refining method of fasudil hydrochloride | 山东新华制药股份有限公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-3199161-B1 | PHARMACEUTICAL PREPARATION | KOWA CO (JP) | 2021-12-15 | — | — | EP | disclosed |
| CN-112010805-A | Method for refining fasudil hydrochloride | 山东威高药业股份有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-111803506-A | Application of fasudil in preparation of medicine for treating developmental stage white matter injury disease | 四川大学华西第二医院 | 2020-10-23 | — | — | CN | disclosed |
| CN-109705096-A | A kind of refining methd of Fasudic hydrochloride | 山东新华制药股份有限公司 | 2019-05-03 | — | — | CN | disclosed |
| CN-104098547-B | A kind of process for purification of Fasudic hydrochloride | 天津红日药业股份有限公司 | 2016-08-24 | — | — | CN | disclosed |
| CN-101962379-B | Method for refining sulfonyl isoquinoline derivative | SHANXI POWERDONE PHARMACEUTICS CO LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101962379-A | Method for refining sulfonyl isoquinoline derivative | SHANXI POWERDONE PHARMACEUTICS CO LTD | 2011-02-02 | — | — | CN | disclosed |
| CN-101962379-A | Method for refining sulfonyl isoquinoline derivative | SHANXI POWERDONE PHARMACEUTICS CO LTD | 2011-02-02 | — | — | CN | disclosed |
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |
| JP-H07118236-A | SULFONYLISOQUINOLINE DERIVATIVE AND AGRICULTURAL AND HORTICULTURAL GERMICIDE | HOKKO CHEM IND CO LTD | 1995-05-09 | — | — | JP | disclosed |
| EP-0187371-B1 | SUBSTITUTED ISOQUINOLINESULFONYL COMPOUNDS | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1991-06-19 | — | — | EP | disclosed |
| EP-0187371-A2 | Substituted isoquinolinesulfonyl compounds | Asahi Kasei Kogyo Kabushiki Kaisha (JP) | 1986-07-16 | — | — | EP | disclosed |