Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.71 |
| ▸ | RAB9A | P51151 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CTSG | P08311 | 9/20 | 0.48 |
| ▸ | CMA1 | P23946 | 9/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836516 | 0.91 | KMT2A (0.60) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7838574 | 0.89 | KMT2A (0.58) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7837364 | 0.85 | KMT2A (0.55) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7837528 | 0.84 | TSHR (0.53) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7838811 | 0.83 | NPC1 (1.00) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7837470 | 0.83 | CTSG (0.53) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7836895 | 0.82 | KMT2A (0.51) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7833371 | 0.82 | CTSG (0.54) | NPC1RAB9AKMT2ACTSGCMA1 | |
| SCHEMBL921684 | 0.81 | NPC1 (0.51) | NPC1RAB9AKMT2AMEN1CTSG | |
| SCHEMBL7835354 | 0.80 | CTSG (0.51) | NPC1RAB9AKMT2AMEN1CTSG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721944-B1 | IMIDAZOLIDINE DERIVATIVE AND USE THEREOF | SUNTORY LTD (JP) | 2001-01-17 | — | — | EP | disclosed |
| US-5691335-A | CARDIOVASCULAR DISORDERS | SUNTORY LIMITED (JP) | 1997-11-25 | — | — | US | disclosed |
| EP-0721944-A1 | IMIDAZOLIDINE DERIVATIVE AND USE THEREOF | SUNTORY LIMITED (JP) | 1996-07-17 | — | — | EP | disclosed |