SCHEMBL7826263

SCHEMBL7826263

CC1CC(=O)CCN1C(=O)Oc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.51
SMN1; SMN2 Q16637 2/20 0.49
ALDH1A1 P00352 2/20 0.49
CHRNA7 P36544 1/20 0.49
HTR3A P46098 1/20 0.49
PARP1 P09874 1/20 0.46
FAAH O00519 2/20 0.44
MAPK1 P28482 2/20 0.42
KDM4E B2RXH2 1/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
NPSR1 Q6W5P4 2/20 0.41
POLB P06746 1/20 0.41
HTT P42858 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5745291 0.82 PARP1 (0.50) GAASMN1; SMN2ALDH1A1CHRNA7HTR3A
SCHEMBL31329634 0.81 HTR2C (0.54) SMN1; SMN2PARP1NPC1RAB9A
SCHEMBL1170552 0.81 HTR2C (0.54) SMN1; SMN2PARP1NPC1RAB9A
SCHEMBL754805 0.81 HTR2C (0.54) SMN1; SMN2PARP1NPC1RAB9A
SCHEMBL5745932 0.79 PARP1 (0.46) GAASMN1; SMN2ALDH1A1CHRNA7HTR3A
SCHEMBL5697246 0.78 ALDH1A1 (0.68) GAASMN1; SMN2ALDH1A1CHRNA7HTR3A
SCHEMBL5467460 0.77 TSHR (0.50) SMN1; SMN2ALDH1A1
SCHEMBL16400715 0.77 ALOX15 (0.47) GAASMN1; SMN2ALDH1A1CHRNA7HTR3A
SCHEMBL6161213 0.77 ALDH1A1 (0.62) GAASMN1; SMN2ALDH1A1CHRNA7HTR3A
SCHEMBL28493796 0.76 POLB (0.37) ALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6303627-B1 FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS ELI LILLY AND COMPANY 2001-10-16 US disclosed
EP-1087962-A4 PREPARATION OF HETEROARYL COMPOUNDS LILLY CO ELI (US) 2001-10-04 EP disclosed
EP-1087962-A1 PREPARATION OF HETEROARYL COMPOUNDS ELI LILLY AND COMPANY (US) 2001-04-04 EP disclosed
WO-1999065487-A1 INHIBITORS OF SEROTONIN REUPTAKE ELI LILLY AND COMPANY (US) 1999-12-23 WO disclosed
WO-1999065896-A1 PREPARATION OF HETEROARYL COMPOUNDS ELI LILLY AND COMPANY (US) 1999-12-23 WO disclosed
EP-0965587-A1 Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake ELI LILLY AND COMPANY (US) 1999-12-22 EP disclosed