Sugi Predict

Sugi Predict / Compounds / SCHEMBL782733

SCHEMBL782733

SCHEMBL782733

Cn1c(=O)oc2ccc(-c3cncc(NS(=O)(=O)C4CC4)c3)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ BRPF1 P55201 2/20 0.42
▸ CYP11B2 P19099 1/20 0.41
▸ PRMT6 Q96LA8 4/20 0.41
▸ KCNJ1 P48048 1/20 0.41
▸ GPR55 Q9Y2T6 2/20 0.41
▸ PRMT1 Q99873 1/20 0.41
▸ PRMT8 Q9NR22 1/20 0.41
▸ FGFR1 P11362 1/20 0.39
▸ FLT1 P17948 1/20 0.39
▸ FGFR2 P21802 1/20 0.39
▸ FGFR4 P22455 1/20 0.39
▸ FGFR3 P22607 1/20 0.39
▸ FLT4 P35916 1/20 0.39
▸ KDR P35968 1/20 0.39
▸ FRS2 Q8WU20 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ TSHR P16473 1/20 0.38
▸ SGK1 O00141 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL782548 0.84 CYP11B2 (0.48) BRPF1CYP11B2KCNJ1GPR55LMNA
SCHEMBL805385 0.83 GPR55 (0.46) BRPF1CYP11B2KCNJ1GPR55FGFR1
SCHEMBL783403 0.81 PTPN5 (0.44) CYP11B2KCNJ1GPR55KDRLMNA
SCHEMBL805366 0.80 CYP11B2 (0.49) CYP11B2KCNJ1GPR55LMNATSHR
SCHEMBL782291 0.78 CYP11B2 (0.41) CYP11B2KCNJ1GPR55ALDH1A1LMNA
SCHEMBL768766 0.77 BRPF1 (0.44) BRPF1PRMT6PRMT1PRMT8FGFR1
SCHEMBL782715 0.75 CYP11B2 (0.53) BRPF1CYP11B2GPR55LMNATSHR
SCHEMBL801469 0.74 GPR55 (0.54) CYP11B2KCNJ1GPR55DDB1CRBN
SCHEMBL782798 0.73 CYP11B2 (0.43) BRPF1CYP11B2
SCHEMBL783680 0.73 CYP11B2 (0.47) CYP11B2KCNJ1GPR55ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2430018-B1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS NOVARTIS AG (CH) 2013-07-03 — — EP disclosed
EP-2430018-B1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYMTHASE INHIBITORS NOVARTIS AG (CH) 2013-07-03 — — EP disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-8455522-B2 Benzoxazolone derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-06-04 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-03-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120071514-A1 BENZOXAZOLONE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS CYP11B2, CYP11B1, CYP21A2 BRPF1 1310/4885CYP11B2 1/4885PRMT6 4612/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.