Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.44 |
| ▸ | SLC9A2 | Q9UBY0 | 3/20 | 0.44 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | AOC2 | O75106 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14607349 | 0.81 | SLC9A1 (0.55) | KDM4EALDH1A1POLBHPGDMAPK1 | |
| SCHEMBL7826071 | 0.80 | ALDH1A1 (0.44) | ALDH1A1SLC9A1SLC9A2SLC9A3 | |
| SCHEMBL7816131 | 0.79 | SLC9A1 (0.43) | KDM4EALDH1A1POLBHPGDMAPK1 | |
| Hydrochloric Acid SCHEMBL7816749 | 0.78 | SLC9A1 (0.43) | KDM4EALDH1A1POLBHPGDMAPK1 | |
| SCHEMBL130491 | 0.77 | KDM4E (0.74) | KDM4EALDH1A1POLBHPGDMAPK1 | |
| SCHEMBL7827914 | 0.76 | AOC2 (0.54) | ALDH1A1POLBHPGDSLC9A1SLC9A2 | |
| SCHEMBL7815979 | 0.75 | SLC9A1 (0.47) | ALDH1A1SLC9A1SLC9A2SLC9A3 | |
| SCHEMBL1388132 | 0.75 | AOC2 (0.58) | SLC9A1AOC2MAPT | |
| Hydrochloric Acid SCHEMBL7825603 | 0.74 | AOC2 (0.53) | ALDH1A1POLBHPGDSLC9A1SLC9A2 | |
| Hydrochloric Acid SCHEMBL7830743 | 0.74 | AOC2 (0.56) | SLC9A1AOC2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1080257-C | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 2002-03-06 | — | — | CN | disclosed |
| EP-0699185-B1 | GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| US-5824691-A | CARDIOVASCULAR, CEREBROVASCULAR, RENAL DISEASES; SHOCK, ARTERIOSCLEROSIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-10-20 | — | — | US | disclosed |
| CN-1123545-A | Guanidine derivatives as inhibitors of Na+/H+ exchange in cells | FUJISAWA PHARMACEUTICAL CO (JP) | 1996-05-29 | — | — | CN | disclosed |
| EP-0699185-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF Na+ /H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994026709-A1 | GUANIDINE DERIVATIVES AS INHIBITORS OF Na+/H+ EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-24 | — | — | WO | disclosed |