Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816507 | 0.92 | POLB (0.45) | DYRK1APOLBMAPTALDH1A1KDM4E | |
| SCHEMBL8069105 | 0.89 | POLB (0.42) | DYRK1APOLBMAPTALDH1A1KDM4E | |
| SCHEMBL7827216 | 0.86 | DYRK1A (0.42) | DYRK1AMAPTALDH1A1KDM4EGSK3A | |
| SCHEMBL7816177 | 0.85 | SMN1; SMN2 (0.44) | DYRK1AMAPTALDH1A1KDM4EGSK3A | |
| SCHEMBL7829950 | 0.84 | DYRK1A (0.53) | DYRK1APOLBMAPTALDH1A1KDM4E | |
| SCHEMBL7826727 | 0.82 | CA12 (0.42) | POLBMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL7823545 | 0.81 | KMT2A (0.52) | POLBMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL9216251 | 0.80 | PARP1 (0.49) | DYRK1AMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL7823420 | 0.78 | DYRK1A (0.44) | DYRK1AMAPTALDH1A1KDM4EHPGD | |
| SCHEMBL7831004 | 0.77 | SMN1; SMN2 (0.44) | MAPTALDH1A1KDM4ELMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |