Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7827211 | 0.90 | HSD17B10 (0.51) | KMT2AMEN1HSD17B10MAPTESR2 | |
| SCHEMBL9216251 | 0.87 | PARP1 (0.49) | KMT2AMEN1HSD17B10MAPTESR2 | |
| SCHEMBL7829950 | 0.86 | DYRK1A (0.53) | KMT2AMEN1HSD17B10MAPTKDM4E | |
| SCHEMBL7827216 | 0.84 | DYRK1A (0.42) | KMT2AMEN1HSD17B10MAPTKDM4E | |
| SCHEMBL7825768 | 0.84 | MAOA (0.47) | KMT2AMEN1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL7831835 | 0.84 | CTSV (0.40) | KMT2AMEN1HSD17B10KDM4EALDH1A1 | |
| SCHEMBL7827951 | 0.81 | DYRK1A (0.44) | HSD17B10MAPTKDM4EALDH1A1HPGD | |
| SCHEMBL7816523 | 0.79 | CHEK1 (0.51) | KMT2AMEN1HSD17B10MAPTKDM4E | |
| SCHEMBL7816177 | 0.78 | SMN1; SMN2 (0.44) | KMT2AMEN1HSD17B10MAPTKDM4E | |
| SCHEMBL7826517 | 0.78 | MAOA (0.52) | HSD17B10MAPTESR2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |