Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.40 |
| ▸ | WNT3A | P56704 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7816177 | 0.93 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNACTNNB1WNT3AL3MBTL1 | |
| SCHEMBL7816507 | 0.85 | POLB (0.45) | LMNAL3MBTL1KMT2AMAPTMEN1 | |
| SCHEMBL7823420 | 0.83 | DYRK1A (0.44) | SMN1; SMN2KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7826811 | 0.82 | ALDH1A1 (0.40) | SMN1; SMN2LMNANPC1RAB9AKMT2A | |
| SCHEMBL7824709 | 0.81 | PDE2A (0.41) | SMN1; SMN2L3MBTL1KMT2AMAPTALDH1A1 | |
| SCHEMBL7831628 | 0.80 | ALK (0.38) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL7826727 | 0.79 | CA12 (0.42) | SMN1; SMN2LMNAL3MBTL1NPC1RAB9A | |
| SCHEMBL7826292 | 0.79 | KDM4E (0.47) | SMN1; SMN2LMNANPC1ABCG2KMT2A | |
| SCHEMBL7827211 | 0.78 | HSD17B10 (0.51) | NPC1KMT2AMAPTMEN1ALDH1A1 | |
| SCHEMBL7832144 | 0.78 | CTSV (0.42) | SMN1; SMN2KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |