SCHEMBL7828090

SCHEMBL7828090

COc1ccc(Oc2ccc(C#N)cc2)cc1.[NaH]

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.54
MAOB P27338 1/20 0.54
LTA4H P09960 2/20 0.52
POLB P06746 3/20 0.52
PARP15 Q460N3 1/20 0.52
PARP10 Q53GL7 1/20 0.52
PARP2 Q9UGN5 1/20 0.52
GAA P10253 1/20 0.52
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
MAPK1 P28482 2/20 0.50
CYP19A1 P11511 1/20 0.50
KDM4E B2RXH2 1/20 0.50
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.50
PKM P14618 1/20 0.50
RAB9A P51151 1/20 0.50
IL18 Q14116 1/20 0.50
AR P10275 1/20 0.50
CACNA1G O43497 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL921496 0.98 MAOA (0.56) MAOAMAOBLTA4HPOLBPARP15
SCHEMBL16604901 0.92 MAOA (0.51) MAOAMAOBLTA4HPOLBPARP15
1,4-Dimethoxybenzene SCHEMBL28617696 0.91 MAOB (0.61) MAOAMAOBPOLBGAAMEN1
SCHEMBL30757515 0.91 MAOB (0.61) MAOAMAOBPOLBGAAMEN1
SCHEMBL103904 0.91 MAOB (0.61) MAOAMAOBPOLBGAAMEN1
SCHEMBL30250275 0.89 MAOA (0.59) MAOAMAOBPOLBPARP15PARP10
Mequinol SCHEMBL6185858 0.88 LTA4H (0.70) MAOAMAOBLTA4HPOLBPARP15
SCHEMBL8546604 0.88 AR (0.51) MAOAMAOBLTA4HPOLBPARP15
SCHEMBL8852392 0.86 PARP15 (0.63) MAOBPOLBPARP15PARP10PARP2
SCHEMBL7041250 0.86 PARP15 (0.63) MAOBPOLBPARP15PARP10PARP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1070054-A1 AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS Takeda Chemical Industries, Ltd. (JP) 2001-01-24 EP disclosed
WO-1999052875-A1 AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-10-21 WO disclosed