Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18371949 | 0.88 | MAPT (0.46) | ALDH1A1TDP1CYP1A2MAPTMAPK1 | |
| SCHEMBL28216693 | 0.85 | ALDH1A1 (0.52) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL17049174 | 0.84 | MAPT (0.55) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL9834203 | 0.83 | ALDH1A1 (0.47) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL28260499 | 0.83 | MAPT (0.47) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL22165764 | 0.83 | MAPT (0.49) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 | |
| SCHEMBL27956774 | 0.82 | HPD (0.48) | ALDH1A1CYP1A2MAPTMAPK1L3MBTL1 | |
| SCHEMBL1572954 | 0.82 | L3MBTL1 (0.56) | ALDH1A1MAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL30619954 | 0.82 | L3MBTL1 (0.56) | ALDH1A1MAPTMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL18371980 | 0.82 | MAPT (0.44) | ALDH1A1TDP1MAPTMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6329389-B1 | HETEROCYCLIC AMINES AND DERIVATIVES, SOMATOSTATIN AND ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-12-11 | — | — | US | disclosed |
| EP-1070054-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | Takeda Chemical Industries, Ltd. (JP) | 2001-01-24 | — | — | EP | disclosed |
| WO-1999052875-A1 | AMINE COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS SOMATOSTATIN RECEPTOR ANTAGONISTS OR AGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-21 | — | — | WO | disclosed |