Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | CTSK | P43235 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29129574 | 0.78 | APLNR (0.41) | DGAT1GAAMEN1KMT2AAPLNR | |
| SCHEMBL23581197 | 0.75 | DGAT1 (0.46) | DGAT1GAAMEN1KMT2ACTSS | |
| SCHEMBL15952952 | 0.75 | DGAT1 (0.46) | DGAT1GAAMEN1KMT2ACTSS | |
| SCHEMBL5073789 | 0.74 | APLNR (0.44) | DGAT1GAAMEN1KMT2AAPLNR | |
| SCHEMBL8486595 | 0.74 | DGAT1 (0.45) | DGAT1GAAMEN1KMT2ACTSS | |
| SCHEMBL284141 | 0.73 | APLNR (0.55) | DGAT1GAAMEN1KMT2AAPLNR | |
| SCHEMBL29129601 | 0.73 | APLNR (0.41) | GAAMEN1KMT2AAPLNRCTSS | |
| SCHEMBL29129533 | 0.73 | APLNR (0.41) | GAAMEN1KMT2AAPLNRCTSS | |
| SCHEMBL31252045 | 0.73 | APLNR (0.39) | DGAT1GAAMEN1KMT2AAPLNR | |
| SCHEMBL25229366 | 0.73 | MEN1 (0.44) | DGAT1GAAMEN1KMT2ACTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1089977-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067219-A1 | COMPOUNDS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1999-12-29 | — | — | WO | disclosed |