Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL410421 | 0.81 | HPGD (0.44) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL3790518 | 0.80 | KMT2A (0.52) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL31540930 | 0.77 | ANPEP (0.55) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL24776531 | 0.76 | KMT2A (0.44) | KMT2AALDH1A1HDAC8HDAC3HDAC4 | |
| SCHEMBL10909813 | 0.75 | HEXA (0.60) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL10699832 | 0.75 | KMT2A (0.65) | ANPEPDPP4KMT2AALDH1A1HDAC8 | |
| SCHEMBL14560522 | 0.75 | ANPEP (0.52) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL12235610 | 0.74 | ANPEP (0.58) | ANPEPDPP4PDE10AKMT2AALDH1A1 | |
| SCHEMBL4959465 | 0.73 | ANPEP (0.51) | ANPEPDPP4KMT2AALDH1A1MEN1 | |
| SCHEMBL7991341 | 0.73 | ALDH1A1 (0.51) | ANPEPDPP4PDE10AKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138585-A1 | PYRIMIDINONES AS PDE10 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2010-12-02 | — | — | WO | disclosed |