Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 2/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.52 |
| ▸ | MAOA | P21397 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 3/20 | 0.50 |
| ▸ | CTSV | O60911 | 1/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | ATP4A | P20648 | 2/20 | 0.48 |
| ▸ | ATP4B | P51164 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815290 | 0.88 | PRKCB (0.60) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL7814978 | 0.84 | MAOA (0.58) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL9084178 | 0.81 | PRKCB (0.60) | MAOAMAOBCTSVCTSLALDH1A1 | |
| SCHEMBL5337023 | 0.80 | MAOA (0.52) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL3148363 | 0.79 | MAOA (0.46) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL7197287 | 0.78 | PRKCB (0.68) | MAOBSIRT2 | |
| SCHEMBL6093904 | 0.77 | TRPM8 (0.48) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL6099181 | 0.77 | CYP1A2 (0.51) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL5339384 | 0.77 | HTR1D (0.48) | TRPM8KDM4EMAPTLTA4HPLA2G2A | |
| SCHEMBL18392212 | 0.77 | TRPM8 (0.53) | TRPM8KDM4EMAPTLTA4HPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397060-B1 | Maleinimide derivatives and their use as medicines | GOEDECKE AG (DE) | 2001-11-21 | — | — | EP | disclosed |
| US-5516915-A | Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1996-05-14 | — | — | US | disclosed |
| US-5380746-A | Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them | GOEDECKE AKTIENGESELLSCHAFT (DE) | 1995-01-10 | — | — | US | disclosed |
| EP-0397060-A2 | Maleinimide derivatives and their use as medicines | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1990-11-14 | — | — | EP | disclosed |