Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.58 |
| ▸ | NOS1 | P29475 | 3/20 | 0.58 |
| ▸ | NOS2 | P35228 | 3/20 | 0.58 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 5/20 | 0.54 |
| ▸ | BACE1 | P56817 | 4/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13326542 | 0.81 | DRD2 (0.65) | ACHEBACE1HRH3BCHECXCR4 | |
| SCHEMBL2536213 | 0.79 | DNMT3A (0.56) | MCHR1ACHEBACE1MEN1KMT2A | |
| SCHEMBL2536211 | 0.79 | DNMT3A (0.56) | MCHR1ACHEBACE1MEN1KMT2A | |
| SCHEMBL27677701 | 0.78 | SCN1A (0.57) | MCHR1ACHEBACE1BCHEMEN1 | |
| SCHEMBL1776541 | 0.78 | ACHE (0.54) | ACHEBACE1HRH3BCHECXCR4 | |
| SCHEMBL1774196 | 0.78 | ACHE (0.54) | ACHEBACE1HRH3BCHECXCR4 | |
| SCHEMBL3322265 | 0.75 | HRH3 (0.56) | ACHEBACE1HRH3BCHECXCR4 | |
| SCHEMBL3324567 | 0.75 | HRH3 (0.56) | ACHEBACE1HRH3BCHECXCR4 | |
| SCHEMBL5307466 | 0.74 | DNMT3A (0.62) | MCHR1ACHEBACE1MEN1KMT2A | |
| SCHEMBL4868726 | 0.74 | ROCK2 (0.56) | ACHEBACE1HRH3BCHECXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1124821-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2001-08-22 | — | — | EP | disclosed |
| WO-2000027842-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2000-05-18 | — | — | WO | disclosed |