Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7828595 | 0.89 | HTT (0.64) | HTTHSD17B10CASP3LMNAMAPT | |
| SCHEMBL7839144 | 0.85 | THRB (0.63) | HTTLMNAMAPTSMN1; SMN2KMT2A | |
| SCHEMBL8650865 | 0.84 | HTT (0.65) | HTTHSD17B10CASP3MAPK1SMN1; SMN2 | |
| SCHEMBL21232451 | 0.84 | HTT (0.58) | HTTHSD17B10CASP3SMN1; SMN2KMT2A | |
| SCHEMBL1142037 | 0.84 | HTT (0.72) | HTTHSD17B10CASP3LMNASMN1; SMN2 | |
| SCHEMBL11639865 | 0.81 | HTT (0.68) | HTTHSD17B10CASP3LMNASMN1; SMN2 | |
| SCHEMBL11547327 | 0.81 | HTT (0.68) | HTTHSD17B10CASP3LMNASMN1; SMN2 | |
| SCHEMBL9182149 | 0.80 | ALDH1A1 (0.79) | HTTHSD17B10MAPK1SMN1; SMN2KMT2A | |
| SCHEMBL10264545 | 0.79 | SMN1; SMN2 (0.67) | HTTHSD17B10LMNAMAPTSMN1; SMN2 | |
| SCHEMBL28208041 | 0.79 | HTT (0.65) | HTTHSD17B10CASP3LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0454501-B1 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | SANKYO CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| EP-0839812-A1 | Preparation of benzylthiazolidine derivatives | Sankyo Company Limited (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5387596-A | Treating arteriosclerosis | SANKYO COMPANY, LIMITED (JP) | 1995-02-07 | — | — | US | disclosed |
| EP-0454501-A2 | Benzylidenethiazolidine derivatives, their preparation and their use for the inhibition of lipid peroxides | Sankyo Company Limited (JP) | 1991-10-30 | — | — | EP | disclosed |