Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MITF | O75030 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4611370 | 0.85 | MTNR1B (0.72) | MTNR1BSMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL1142037 | 0.85 | HTT (0.72) | HTTHSD17B10CASP3MTNR1BSMN1; SMN2 | |
| SCHEMBL7828595 | 0.84 | HTT (0.64) | HTTHSD17B10CASP3MTNR1BSMN1; SMN2 | |
| SCHEMBL7828591 | 0.84 | HTT (0.64) | HTTHSD17B10CASP3MTNR1BSMN1; SMN2 | |
| SCHEMBL11639865 | 0.82 | HTT (0.68) | HTTHSD17B10CASP3SMN1; SMN2KMT2A | |
| SCHEMBL11547327 | 0.82 | HTT (0.68) | HTTHSD17B10CASP3SMN1; SMN2KMT2A | |
| SCHEMBL832694 | 0.82 | LTA4H (0.65) | HTTKMT2AMEN1ALDH1A1NR1H4 | |
| SCHEMBL9182149 | 0.81 | ALDH1A1 (0.79) | HTTHSD17B10SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL31336565 | 0.81 | ALDH1A1 (0.54) | HTTMTNR1BSMN1; SMN2ALDH1A1MTNR1A | |
| SCHEMBL6690315 | 0.81 | HTT (0.55) | HTTHSD17B10SMN1; SMN2KMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710139-A | Heterocyclic compounds | ASTRA AB (SE) | 1998-01-20 | — | — | US | disclosed |
| EP-0736032-A1 | HETEROCYCLIC COMPOUNDS | Astra Aktiebolag (SE) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017410-A1 | HETEROCYCLIC COMPOUNDS | ASTRA AKTIEBOLAG (SE) | 1995-06-29 | — | — | WO | disclosed |