Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | FABP7 | O15540 | 1/20 | 0.39 |
| ▸ | FABP3 | P05413 | 1/20 | 0.39 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336545 | 0.88 | EDNRA (0.51) | EDNRAHCRTR2EDNRBNPC1RAB9A | |
| SCHEMBL7827271 | 0.87 | EDNRA (0.47) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6541879 | 0.82 | EDNRA (0.41) | EDNRAEDNRB | |
| SCHEMBL6542057 | 0.81 | EDNRA (0.51) | EDNRAHCRTR2EDNRBNPC1RAB9A | |
| SCHEMBL6541829 | 0.80 | EDNRA (0.43) | EDNRAEDNRBFABP7FABP3FABP5 | |
| SCHEMBL6542600 | 0.78 | EDNRA (0.44) | EDNRAEDNRBNPC1RAB9ACTNNB1 | |
| SCHEMBL6541685 | 0.78 | EDNRA (0.47) | EDNRAHCRTR2EDNRB | |
| SCHEMBL6542606 | 0.78 | EDNRA (0.43) | EDNRANPC1RAB9AKMT2AFABP3 | |
| SCHEMBL6541832 | 0.78 | EDNRA (0.46) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL6542684 | 0.77 | EDNRA (0.42) | EDNRAEDNRBNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |