Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.58 |
| ▸ | CES1 | P23141 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293634 | 0.80 | CES2 (0.60) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL29952517 | 0.80 | CES2 (0.60) | CES2CES1ALDH1A1POLBPTGS1 | |
| Water SCHEMBL10353121 | 0.78 | CES2 (0.58) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL4770585 | 0.78 | CES2 (0.58) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL9113114 | 0.78 | CES2 (0.58) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL7006496 | 0.78 | CES2 (0.58) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL15563306 | 0.78 | ALDH1A1 (0.55) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL15563304 | 0.78 | ALDH1A1 (0.55) | CES2CES1ALDH1A1POLBPTGS1 | |
| SCHEMBL7830798 | 0.76 | KDM4E (0.55) | ALDH1A1PTGS1PTGS2HPGDCYP2C19 | |
| SCHEMBL18334775 | 0.75 | CES2 (0.54) | CES2CES1ALDH1A1POLBPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686636-B1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA CO (JP) | 2001-04-04 | — | — | EP | disclosed |
| US-5840895-A | INTERMEDIATES FOR ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1998-11-24 | — | — | US | disclosed |
| US-5686442-A | ANTIALLERGENS | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0686636-A1 | TRICYCLIC BENZAZEPINE AND BENZOTHIAZEPINE DERIVATIVES | MEIJI SEIKA KABUSHIKI KAISHA (JP) | 1995-12-13 | — | — | EP | disclosed |